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Induced pluripotent stem cells (IPS): current situation and prospect

Han Weidong,Zhao Yali,Fu Xiaobing

Strategic Study of CAE 2009, Volume 11, Issue 5,   Pages 81-87

Abstract:

Differentiated somatic cells can be reprogrammed into induced pluripotentstem cells (iPS) by transduction of a defined transcription factors.However, the present development of pluripotent cells from individual somatic cells just opened up anew door to stem cell research world, much work remains to be done before iPS cells can be considered

Keywords： somatic cells     reprogramming     iPS cells    

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Oocyte-associated transcription factors in reprogramming after somatic cell nuclear transfer: a review

Fengxia YIN,Hui LIU,Shorgan BOU,Guangpeng LI

Frontiers of Agricultural Science and Engineering 2014, Volume 1, Issue 2,   Pages 104-113 doi: 10.15302/J-FASE-2014003

Abstract: Oocytes are unique cells with the inherent capability to reprogram nuclei.The reprogramming of the somatic nucleus from its original cellular state to a totipotent state is essentialfor term development after somatic cell nuclear transfer.The chromatin of somatic nuclei can be reprogrammed by factors in the egg cytoplasm whose natural functiontranscription factors in the cytoplast may be critical as has been demonstrated for induced pluripotent stem cells

Keywords： nuclear reprogramming     somatic cell     transcription factors     transcriptomics    

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Factors influencing the somatic cell nuclear transfer efficiency in pigs

Yong JIN, Manling ZHANG, Xinrong JU, Shuang LIANG, Qiang XIONG, Lihua ZHAO, Xiaowei NIE, Daorong HOU, Qiang LIU, Junzheng WANG, Chenyu WANG, Xiaokang LI, Lining ZHANG, Xiaorui LIU, Ying WANG, Haiyuan YANG, Yifan DAI, Rongfeng LI

Frontiers of Agricultural Science and Engineering 2019, Volume 6, Issue 1,   Pages 73-80 doi: 10.15302/J-FASE-2018220

Abstract: The results demonstrated that cells at high confluence (>90%) used as donor cell resulted in highernumber of live offspring born per reconstructed embryo transferred to recipients) compared with the cellsCells with four, five and six passages compromised the pregnancy and delivery rates compared with firstpassage cells.The number of blastocysts transferred by somatic cell nuclear transfer (SCNT) did not significantly affect

Keywords： blastocyst     donor cell     estrus synchronization     pregnancy rate     pig cloning     somatic cell nuclear transfer    

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Factors affecting early embryonic development in cattle: relevance for bovine cloning

Yanna DANG, Kun ZHANG

Frontiers of Agricultural Science and Engineering 2019, Volume 6, Issue 1,   Pages 33-41 doi: 10.15302/J-FASE-2018228

Abstract: Meanwhile, early embryo development is significant for somatic cell nuclear transfer in cattle as a large

Keywords： bovine cloning     embryo development     somatic cell nuclear transfer     X-inactive specific transcript    

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Porcine pluripotent stem cells: progress, challenges and prospects

Jianyong HAN, Yi-Liang MIAO, Jinlian HUA, Yan LI, Xue ZHANG, Jilong ZHOU, Na LI, Ying ZHANG, Jinying ZHANG, Zhonghua LIU

Frontiers of Agricultural Science and Engineering 2019, Volume 6, Issue 1,   Pages 8-27 doi: 10.15302/J-FASE-2018233

Abstract:

Pluripotent stem cells (PSCs) are characterized by their capacity for high self-renewal and multipledifferentiation potential and include embryonic stem cells, embryonic germ cells and induced PSCs.

Keywords： embryonic germ cells     embryonic stem cells     induced pluripotent stem cells     pigs     pluripotent stem cells    

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Generation and repair of AID-initiated DNA lesions in B lymphocytes

Zhangguo Chen,Jing H. Wang

Frontiers of Medicine 2014, Volume 8, Issue 2,   Pages 201-216 doi: 10.1007/s11684-014-0324-4

Abstract: In mammalian B cells, this process includes somatic hypermutation (SHM) and class switch recombinationThus, AID poses a threat to the genome of B cells if AID-initiated DNA lesions cannot be properly repaired

Keywords： class switch recombination     somatic hypermutation     activation-induced deaminase     DNA repair     genomic instability    

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Determination of telomerase activity in stem cells and non-stem cells of breast cancer

LI Zhi, HE Yanli, ZHANG Jiahua, ZHANG Jinghui, HUANG Tao

Frontiers of Medicine 2007, Volume 1, Issue 3,   Pages 294-298 doi: 10.1007/s11684-007-0056-9

Abstract: Although all normal tissue cells, including stem cells, are genetically homologous, variation in geneIn normal adults, telomerase activation mainly presents in tissue stem cells and progenitor cells givingand only minorities of cells, designated as cancer stem cells, undergo processes analogous to the self-renewalcells that were phenotypically sorted by examining surface marker expression.The results indicated that cancer stem cells show a higher level of enzyme activity than non-stem cells
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Innate and adaptive T cells in influenza disease

Simone Nüssing, Sneha Sant, Marios Koutsakos, Kanta Subbarao, Thi H.O. Nguyen, Katherine Kedzierska

Frontiers of Medicine 2018, Volume 12, Issue 1,   Pages 34-47 doi: 10.1007/s11684-017-0606-8

Abstract: and antibody-producing B cells) achieve viral clearance and host recovery.Adaptive T and B cells maintain immunological memory and provide protection against subsequent infectionsRecent studies also shed light on the role of innate T-cells (MAIT cells, gd T cells, and NKT cells)We summarize the current knowledge on influenza-specific innate MAIT and gd T cells as well as adaptiveCD8+ and CD4+ T cells, and discuss how these responses can be harnessed by novel

Keywords： influenza     innate T cells     CD4+ and CD8+ T cells     vaccination    

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Reprogramming of the pig primordial germ cells into pluripotent stem cells: a brief review

Qijing LEI, Qin PAN, Shuai YU, Na LI, Shulin CHEN, Kuldip SIDHU, Jinlian HUA

Frontiers of Agricultural Science and Engineering 2019, Volume 6, Issue 1,   Pages 28-32 doi: 10.15302/J-FASE-2018222

Abstract:

Primordial germ cells (PGCs) are regarded as unipotent cells that can produce only either spermatogoniaHowever, PGCs can be converted into the pluripotent state by first dedifferentiation to embryonic germ cellsand then by reprogramming to induce them to become pluripotent stem cells (iPSCs).These two stages can be completely implemented with mouse cells.

Keywords： pig     pluripotent stem cells     primordial germ cells     reprogramming    

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4-1BBL expressed by eukaryotic cells activates immune cells and suppresses the progression of murine

Hui QIU, Hui ZHANG, Zuohua FENG

Frontiers of Medicine 2009, Volume 3, Issue 1,   Pages 20-25 doi: 10.1007/s11684-009-0006-9

Abstract: The function of 4-1BB/4-1BBL expressed by the immune cells has been the focus for many tumor immunotherapyIn this study, 4-1BBL was expressed in non-immune cells and non-tumor cells, and the role of 4-1BBL in-1BBL cDNA sequence was constructed, and the plasmid was transfected into baby hamster kidney (BHK) cellsand murine muscle cells by means of lipofectin-mediated or naked plasmid DNA injection into the muscleThe study demonstrated that the molecule 4-1BBL expressed by BHK cells could enhance the proliferation

Keywords： 4-1BB ligand     tumor immunotherapy     tumor microenvironment    

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The past, present and future of bovine pluripotent stem cells: a brief overview

Xiuchun TIAN

Frontiers of Agricultural Science and Engineering 2019, Volume 6, Issue 1,   Pages 3-7 doi: 10.15302/J-FASE-2018247

Abstract:

Although the pursuit of bovine embryonic stem cells started more than 26 years ago for the purposeof gene-targeting, true pluripotent stem cells in this economically important species are still elusiveWith the rapid advances in genome-editing and cloning using homologously recombined somatic cells, theneed for pluripotent stem cells for precise genetic modification in any species became questionable.pluripotency circuitry across mammalian species may be the main objective for studying pluripotent stem cells

Keywords： bovine     embryonic     induced     pluripotent stem cells    

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Comparison of human nasal epithelial cells grown as explant outgrowth cultures or dissociated tissue

Jian Jiao, Na Meng, Hong Wang, Luo Zhang

Frontiers of Medicine 2013, Volume 7, Issue 4,   Pages 486-491 doi: 10.1007/s11684-013-0287-x

Abstract: cell growth characteristics, ciliated cell differentiation, and function of human nasal epithelial cellsdensity appeared at 7th–10th culture day and declined with time, with the lifespan of ciliated cellsOverall, 10% of the cells in explant cultures and 20% of the cells in the dissociated tissue culturestissue culture techniques are suitable for growing well-differentiated nasal ciliated and non-ciliated cells, which have growth characteristics and ciliary activity similar to those of nasal epithelial cells 

Keywords： ciliated cells     ciliary beat frequency     dissociated tissue culture     explant culture     nasal epithelial cells    

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Capacity of human umbilical cord-derived mesenchymal stem cells to differentiate into sweat gland-likecells: a preclinical study

Siming Yang, Kui Ma, Changjiang Feng, Yan Wu, Yao Wang, Sha Huang, Xiaobing Fu

Frontiers of Medicine 2013, Volume 7, Issue 3,   Pages 345-353 doi: 10.1007/s11684-013-0282-2

Abstract:

Human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) possess various advantageous propertiespotential, multi-lineage differentiation potential and capacity for differentiating into sweat gland-like cellsculture media (ASFCM) in order to determine their potential for differentiation into sweat gland-like cellsMoreover, cells cultured in ASFCM showed vigorous proliferation comparable to those of cells grown inMorphology of hUC-MSCs cultured in ASFCM was comparable to those of cells grown under classical culture

Keywords： umbilical cord     mesenchymal stem cells     sweat gland     preclinical    

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Microbial electrolysis cells with biocathodes and driven by microbial fuel cells for simultaneous enhanced

Jingya SHEN,Yuliang SUN,Liping HUANG,Jinhui YANG

Frontiers of Environmental Science & Engineering 2015, Volume 9, Issue 6,   Pages 1084-1095 doi: 10.1007/s11783-015-0805-y

Abstract: Previous tests have primarily examined Cu(II) and Co(II) removal in microbial electrolysis cells (MECs

Keywords： biocathode     microbial electrolysis cell     microbial fuel cell     Cu(II) removal     Co(II) removal    

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Highlights for special issue on “Large Animal Stem Cells”

Jianyong HAN

Frontiers of Agricultural Science and Engineering 2019, Volume 6, Issue 1,   Pages 1-2 doi: 10.15302/J-FASE-2019251

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Title Author Date Type Operation

Induced pluripotent stem cells (IPS): current situation and prospect

Han Weidong,Zhao Yali,Fu Xiaobing

Journal Article

Oocyte-associated transcription factors in reprogramming after somatic cell nuclear transfer: a review

Fengxia YIN,Hui LIU,Shorgan BOU,Guangpeng LI

Journal Article

Factors influencing the somatic cell nuclear transfer efficiency in pigs

Yong JIN, Manling ZHANG, Xinrong JU, Shuang LIANG, Qiang XIONG, Lihua ZHAO, Xiaowei NIE, Daorong HOU, Qiang LIU, Junzheng WANG, Chenyu WANG, Xiaokang LI, Lining ZHANG, Xiaorui LIU, Ying WANG, Haiyuan YANG, Yifan DAI, Rongfeng LI

Journal Article

Factors affecting early embryonic development in cattle: relevance for bovine cloning

Yanna DANG, Kun ZHANG

Journal Article

Porcine pluripotent stem cells: progress, challenges and prospects

Jianyong HAN, Yi-Liang MIAO, Jinlian HUA, Yan LI, Xue ZHANG, Jilong ZHOU, Na LI, Ying ZHANG, Jinying ZHANG, Zhonghua LIU

Journal Article

Generation and repair of AID-initiated DNA lesions in B lymphocytes

Zhangguo Chen,Jing H. Wang

Journal Article

Determination of telomerase activity in stem cells and non-stem cells of breast cancer

LI Zhi, HE Yanli, ZHANG Jiahua, ZHANG Jinghui, HUANG Tao

Journal Article

Innate and adaptive T cells in influenza disease

Simone Nüssing, Sneha Sant, Marios Koutsakos, Kanta Subbarao, Thi H.O. Nguyen, Katherine Kedzierska

Journal Article

Reprogramming of the pig primordial germ cells into pluripotent stem cells: a brief review

Qijing LEI, Qin PAN, Shuai YU, Na LI, Shulin CHEN, Kuldip SIDHU, Jinlian HUA

Journal Article

4-1BBL expressed by eukaryotic cells activates immune cells and suppresses the progression of murine

Hui QIU, Hui ZHANG, Zuohua FENG

Journal Article

The past, present and future of bovine pluripotent stem cells: a brief overview

Xiuchun TIAN

Journal Article

Comparison of human nasal epithelial cells grown as explant outgrowth cultures or dissociated tissue

Jian Jiao, Na Meng, Hong Wang, Luo Zhang

Journal Article

Capacity of human umbilical cord-derived mesenchymal stem cells to differentiate into sweat gland-likecells: a preclinical study

Siming Yang, Kui Ma, Changjiang Feng, Yan Wu, Yao Wang, Sha Huang, Xiaobing Fu

Journal Article

Microbial electrolysis cells with biocathodes and driven by microbial fuel cells for simultaneous enhanced

Jingya SHEN,Yuliang SUN,Liping HUANG,Jinhui YANG

Journal Article

Highlights for special issue on “Large Animal Stem Cells”

Jianyong HAN

Journal Article